Activity Number:
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482
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Type:
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Topic Contributed
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Date/Time:
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Wednesday, August 12, 2015 : 8:30 AM to 10:20 AM
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Sponsor:
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Committee on ASA Archives and Historical Materials
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Abstract #315633
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View Presentation
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Title:
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The History of Cardiovascular Clinical Trials at the National Heart, Lung, and Blood Institute
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Author(s):
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Myron A. Waclawiw* and Nancy Geller
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Companies:
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National Heart, Lung, and Blood Institute and NIH/NHLBI
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Keywords:
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Cardiovascular Clinical Trials ;
Greenberg Report ;
National Heart, Lung, and Blood Institute
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Abstract:
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The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health has undertaken cooperative multicenter clinical trials in heart disease since the early 1960s. This talk describes the evolution of trial structure and draws on several of the best known trials as examples of how these large, cooperative trials were organized and carried out. In particular, we highlight some early and more recent design and biostatistical advances that selected trials have developed or used effectively to answer important public health questions. Many of the design, organizational characteristics, and methods for monitoring modern clinical trials were implemented as a result of the Greenberg Report and were first used in the Coronary Drug Project. While more recent studies employed more efficient organizations, newer designs, and newer monitoring guidelines, the genesis of multicenter clinical trial practice in heart disease was outlined in the 1960s, and that early stucture has endured the test of time.
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Authors who are presenting talks have a * after their name.
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