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Activity Number: 86
Type: Contributed
Date/Time: Sunday, August 9, 2015 : 4:00 PM to 5:50 PM
Sponsor: Biopharmaceutical Section
Abstract #315443 View Presentation
Title: A Simultaneous Testing Strategy for Meta-Analysis of a Dichotomous Endpoint
Author(s): Radha Railkar* and Devan Mehrotra
Companies: Merck and Merck
Keywords: meta-analysis ; weighted average ; optimal weights ; interaction
Abstract:

A meta-analysis involves combining data from multiple studies to achieve higher statistical power for the measure of interest. A weighted average of the measure of interest is typically computed using weights based on the inverse of the study-specific variances (INVAR) or the study-specific sample sizes (SSIZE). When the measure of interest is the difference between success proportions on 2 treatments, the INVAR and SSIZE weights are optimal if the differences between proportions are constant across studies on the proportion and logit scales, respectively. If a scale exists on which treatment differences are constant across studies, the optimal weights can be derived. However the existence of such a scale is not known a priori, so an optimal weighting strategy cannot be pre-specified. We propose an alternative testing strategy based on the simultaneous use of 3 test statistics, each involving a weighted average of within study differences between proportions. The optimal weights for no treatment by study interaction on 3 common scales, i.e., proportion, logit and log will be used. We will demonstrate the power advantages of this procedure over existing procedures via simulation.


Authors who are presenting talks have a * after their name.

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