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Activity Number: 482
Type: Topic Contributed
Date/Time: Wednesday, August 12, 2015 : 8:30 AM to 10:20 AM
Sponsor: Committee on ASA Archives and Historical Materials
Abstract #315338
Title: Recent History of Clinical Trials and Survival Analysis
Author(s): David Harrington*
Companies: Dana-Farber Cancer Institute
Keywords: clinical crials ; survival analysis ; group sequential designs
Abstract:

Methods for analyzing time to event data have been one of the important tools in the analysis in the design and analysis of clinical trials. This talk will examine the methodologic advances in survival analysis that have responded to important problems in the study of chronic diseases, including regression models, group sequential designs in cancer clinical trials, frailty models, robust methods for exploring random effects in multi-center trials, and causal models in HIV and other settings where non-adherence threatens the interpretation of a trial. We will also explore instances where advances in survival analysis were important parts of newer approaches in statistics generally, such as semi-parametric inference.

Authors who are presenting talks have a * after their name.

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