JSM 2015 Preliminary Program

Online Program Home
My Program

Abstract Details

Activity Number: 659
Type: Contributed
Date/Time: Thursday, August 13, 2015 : 8:30 AM to 10:20 AM
Sponsor: Biopharmaceutical Section
Abstract #315124 View Presentation
Title: Statistical Considerations in Detecting Circulating Tumor DNA Using Digital PCR
Author(s): Shibing Deng* and Maruja Lira
Companies: Pfizer Inc. and Pfizer Inc.
Keywords: Cancer ; biomarker ; digital PCR
Abstract:

Circulating tumor DNA (ctDNA) provides a non-invasive and effective method for the detection, monitoring and treatment of cancer. It has been suggested to be a promising biomarker for patient disease prognosis and response to treatment. Recent developments in digital PCR (dPCR) make it a sensitive technology for ctDNA detection. Under assumption of Poisson distribution, the expected count of ctDNA in a patient blood sample was estimated from dPCR data. A limit of detection (LoD) for the assay was developed to allow an accurate detection of ctDNA in a sample. The proposed LoD was consistent with the data generated from several serial dilution experiments.

Authors who are presenting talks have a * after their name.

Back to the full JSM 2015 program





For program information, contact the JSM Registration Department or phone (888) 231-3473.

For Professional Development information, contact the Education Department.

The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.

2015 JSM Online Program Home