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Activity Number: 51
Type: Invited
Date/Time: Sunday, August 9, 2015 : 4:00 PM to 5:50 PM
Sponsor: ENAR
Abstract #314525 View Presentation
Title: Some Experience with Biomarker-Driven Cancer Clinical Trials
Author(s): Michael LeBlanc*
Companies: Fred Hutchinson Cancer Research Center
Keywords: clinical ; trial ; genomic ; biomarker ; targetted
Abstract:

The incorporation of genomic profiling as part of the cancer clinical trials designs has been realized in several disease settings. Designs include a wide variety randomized Phase II, Phase III and Phase II/III strategies and typically focus on inferences involving one or more genomically defined subgroups of patients. We will describe some experience in designing and implementing such biomarker-driven trials in several disease settings including gastrointestinal, genitourinary and lung cancer as part of the NCI National Clinical Trial Network. The discussion will include the recently activated biomarker-driven clinical trial for patients with advanced squamous cell lung cancer (Lung-MAP) which genomic profiling to assign patients to multiple randomized substudies.

Authors who are presenting talks have a * after their name.

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