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Activity Number: 153
Type: Invited
Date/Time: Monday, August 10, 2015 : 10:30 AM to 12:20 PM
Sponsor: WNAR
Abstract #314372 View Presentation
Title: Personalized Evaluation of Biomarker Value in Risk Prediction and Treatment Selection: A Cost-Benefit Perspective
Author(s): Ying Huang* and Eric Laber
Companies: Fred Hutchinson Cancer Research Center and North Carolina State University
Keywords: Adaptive bootstrap ; Biomarker ; Cost-Benefit ; Semiparametric location-scale model ; Subject-specific expected benefit ; Treatment selection
Abstract:

In clinical practice, for a patient who is facing a treatment decision in order to prevent or control a disease outcome, the added value of information provided by a biomarker depends on the individual patient's expected response to treatment with and without the biomarker, as well as his/her tolerance of disease and treatment harm. However, individualized estimators of the value of a biomarker are lacking. In this project, we propose a new graphical tool named the subject-specific expected benefit curve for quantifying the personalized value of a biomarker in aiding a treatment decision. We develop semiparametric estimators for two general settings: i) when biomarker data are available from a randomized trial; and ii) when biomarker data are available from a cohort or a cross-sectional study, together with external information about a multiplicative treatment effect. We also develop adaptive bootstrap confidence intervals for consistent inference in the presence of non-regularity. The proposed method is illustrated by examples in cancer prevention.


Authors who are presenting talks have a * after their name.

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