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Activity Number: 577
Type: Invited
Date/Time: Wednesday, August 12, 2015 : 2:00 PM to 3:50 PM
Sponsor: ENAR
Abstract #314325
Title: Secondary Prevention Trials for Dementia: Lessons Learned from a Primary Prevention Trial
Author(s): Richard J. Kryscio*
Companies: University of Kentucky
Keywords: dementia ; primary prevention ; secondary prevention

There is considerable interest in preventing dementia since efforts to treat the disease have not been effective and since the biological processes promoting the deficits in memory and activities of daily living associated with dementia occur slowly over many years prior to a clinical diagnosis. This presentation will provide an overview of this dementing process and its ramifications for designing both primary prevention trials and secondary prevention trials in this disease. Specific focus will be on composite endpoints applied to subjects with signs of early deficits including subjective memory complaints. Data from the PREADViSE project will be used to motivate the overview. The latter is a primary prevention trial on the use of vitamin E and selenium used alone or in combination to prevent Alzheimer's disease which enrolled 7,547 men but closed due to an interim analysis on its parent trial: a prostate cancer prevention study. It then evolved into an anti-oxidant exposure study of 4,271 of its participants with over 310 incident cases of dementia observed among all participants to date. The blind on this study will be broken in early 2015.

Authors who are presenting talks have a * after their name.

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