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Activity Number: 106
Type: Invited
Date/Time: Monday, August 10, 2015 : 8:30 AM to 10:20 AM
Sponsor: Section on Statistics in Epidemiology
Abstract #314214
Title: Quantification of Multiple Tumor Clones Using Gene Array Data
Author(s): Charles Kooperberg* and Yichen Cheng and James Y. Dai
Companies: Fred Hutchinson Cancer Research Center and Fred Hutchinson Cancer Research Center and Fred Hutchinson Cancer Research Center
Keywords:
Abstract:

It is not uncommon that tumor samples are in fact mixtures of several "clones" and possible also some normal cells. We describe a likelihood based algorithm for determining what percentage of the tumor sample particular clones are from, as well as the copy number alterations of each of these clones, using nowadays quite economical gene array data. We illustrate our results on a cell-line data set of Barrett's esophagus, a pre-curser of esophageal cancer. association for each feature, which provides evidence of feature-level association.

Authors who are presenting talks have a * after their name.

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