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Activity Number: 288
Type: Invited
Date/Time: Tuesday, August 11, 2015 : 8:30 AM to 10:20 AM
Sponsor: Section on Statistics in Imaging
Abstract #314204 View Presentation
Title: EEG/MEG Source Reconstruction with Spatial-Temporal Two-Way Regularized Regression
Author(s): Jianhua Huang*
Companies: Texas A&M University
Keywords: inverse problem ; EEG/MEG ; graph Laplacian ; sparsity ; roughness penalty ; functional data

In this work, we propose a spatial-temporal two-way regularized regression method for reconstructing neural source signals from EEG/MEG time course measurements. The proposed method estimates the dipole locations and amplitudes simultaneously through minimizing a single penalized least squares criterion. The novelty of our methodology is the simultaneous consideration of three desirable properties of the reconstructed source signals: spatial focality, spatial smoothness, and temporal smoothness. The desirable properties are achieved by using three separate penalty functions in the penalized regression framework. Specifically, we impose a roughness penalty in the temporal domain for temporal smoothness, and a sparsity-inducing penalty and a graph Laplacian penalty in the spatial domain for spatial focality and smoothness. We develop a computational efficient multilevel block coordinate descent algorithm to implement the method. Using a simulation study with several settings of different spatial complexity and two real MEG examples, we show that the proposed method outperforms existing methods that use only a subset of the three penalty functions

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