Using Novel Phase I Clinical Trial Designs in Practice

• Activity Number: 337
• Type: Invited
• Date/Time: Tuesday, August 11, 2015 : 10:30 AM to 12:20 PM
• Sponsor: WNAR
• Author(s): Ying Yuan*
• Companies: MD Anderson Cancer Center
• Keywords: Bayesian adaptive design ; dosing finding ; maximum tolerated dose ; phase I clinical trial

Abstract

In this talk, I will describe a case study of using a novel Bayesian adaptive design, namely, the Bayesian model averaging continual reassessment method, to conduct a real-world phase I clinical trial, where the lead PI at one site, the statisticians at another site, and the statistical consultant at the third site. This case study highlights the feasibility of using novel trial designs through close collaboration between statisticians and the medical PI. A discussion of the practical considerations that have arisen during the trial will be provided, and some recent development on phase I adaptive designs will also be covered.