JSM 2015 Preliminary Program

Online Program Home
My Program

Abstract Details

Activity Number: 577
Type: Invited
Date/Time: Wednesday, August 12, 2015 : 2:00 PM to 3:50 PM
Sponsor: ENAR
Abstract #314161
Title: Novel Outcome Measures for Clinical Trials Targeting the Earliest Stages of Alzheimer's Disease
Author(s): Steven D. Edland* and M. Colin Ard
Companies: UC San Diego and UC San Diego
Keywords: optimal endpoint ; clinical trial ; composite ; sample size ; power ; Alzheimer's
Abstract:

Despite substantial investments, treatments to slow the progression of Alzheimer's disease have been elusive. Statistical consideration of power and sample size is a central concern, especially as we move to performing trials targeting the earliest stages of disease, when treatments may be most effective, but when symptoms of disease are subtle and treatment effects difficult to discern. To address this concern, statistical methods to derive new outcome measures more sensitive to the earliest stages of disease have been developed. This talk will illustrate by way of example the various techniques that have been developed to construct more sensitive outcome measures, including methods to derive composite endpoints formed by combining scales or subscales from existing assessment batteries, and the use of item response theory and other weighting methods to optimize the performance of new scales given their component elements. Based on application to placebo arm data from completed trials, these methods result in outcome measures with substantively improved signal-to-noise properties and promise to increase the probability that effective treatments of disease will be identified.


Authors who are presenting talks have a * after their name.

Back to the full JSM 2015 program





For program information, contact the JSM Registration Department or phone (888) 231-3473.

For Professional Development information, contact the Education Department.

The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.

2015 JSM Online Program Home