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293 * Tue, 8/5/2014, 8:30 AM - 10:20 AM CC-151B
Dose Finding, Dose Range, and Oncology Trials — Contributed Papers
Biopharmaceutical Section
Chair(s): Jiang Qian, AbbVie   
8:35 AM A Bayesian Oncology Dose-Ranging Study Design Bo Ma, GlaxoSmithKline ; Ohad Amit, GlaxoSmithKline ; Yuehui Wu, GlaxoSmithKline
8:50 AM Resampling-Based Approach for Assessing Clinical Utility of Tumor Measurement-Based Metrics Using the RECIST 1.1 Data Warehouse Ming-Wen An, Vassar College ; Sumithra Mandrekar, Mayo Clinic ; Yu Han, University of Rochester ; Daniel Sargent, Mayo Clinic
9:05 AM A Simulation-Based Comparison of Two Adaptive Designs in Phase I Dose Finding Oncology Trial Xiaoling Wu, Celgene Corporation ; Shaoyi Li, Celgene Corporation
9:20 AM A Semiparamtric Estimation Approach for Dealing with Treatment Switching in Randomized Oncology Trials Jin Zhang, Merck ; Cong Chen, Merck
9:35 AM Dose Finding for Drug Combination in Early Cancer Phase I Trials Using Conditional Escalation with Overdose Control Mourad Tighiouart, Cedars-Sinai Medical Center ; Andre Rogatko, Cedars-Sinai Medical Center ; Steven Piantadosi, Cedars-Sinai Medical Center
9:50 AM Finding Optimal Treatment Dose Using Outcome-Weighted Learning Guanhua Chen, University of North Carolina at Chapel Hill ; Michael Kosorok, University of North Carolina at Chapel Hill ; Donglin Zeng, University of North Carolina at Chapel Hill
10:05 AM Dose-Finding Designs for Phase I Clinical Trials in Oncology and Use of Selective Phenotypying to Increase Power of Genetic Association Studies Yunfei Wang, Children's National Medical Center ; Ethan M. Lange, University of North Carolina



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