Exploring Heterogeneity in High-Throughout Biological Data for Application in Translation Medicine: Between Cell Lines and Patients

• Activity Number: 58
• Type: Topic Contributed
• Date/Time: Sunday, August 3, 2014 : 4:00 PM to 5:50 PM
• Sponsor: Biometrics Section
• Author(s): Ker-Chau Li*+
• Companies: Academia Sinica
• Keywords: high throughput data ; bioinformatics

Abstract

Between and within sample heterogeneity presents one of the major challenges in biomedical studies. Cell lines are commonly used to probe biological functions. However, inconsistency between the cell line data and patient outcome such as the response to drug treatment is prevalently observed. Thus an important issue is how to explore high throughput molecular data gathered from both sources to reveal and exploit critical heterogeneity for applications in targeted or precision medicine. Using some examples, the underlying biological rationales were be used to formulate the problems and methods to address the issue will be presented.