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Activity Number: 232
Type: Contributed
Date/Time: Monday, August 4, 2014 : 2:00 PM to 3:50 PM
Sponsor: Biometrics Section
Abstract #313242 View Presentation
Title: The Role of Akaike Weights in Model Selection
Author(s): Jessica K. Kohlschmidt*+ and Kati S. Maharry and Clara D. Bloomfield
Companies: Ohio State University and Ohio State University and Ohio State University
Keywords: Modeling ; AIC ; Akaike weights ; Oncology
Abstract:

When investigating the usefulness of a molecular marker, multivariable models are often considered. These models are used to analyze the influence of a marker on outcome while considering variables that have been shown to be important. There are often several models that could be used to describe outcome using the variables that have been collected. The question becomes which model provides the best insight into the data. In this talk, we will look at a number of models that could be used for a particular analysis and then using Akaike weights make a determination as to the model that is most likely to be the "best". This is a statistical approach to modeling instead of choosing a model based on perceived biological relationships. The approach using Akaike weights considers the possible models and uses the cumulative information to make conclusions regarding the feasibility of each of the models in light of the data available. We provide this as an alternative approach to presenting models in oncology research. As we have more data available to researchers on a fixed number of patients (i.e. massive array data) we are in need of solutions such as this to aid in research decisions.


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