A Robust Association Test for SNPs on the X Chromosome in Case Control GWAS

• Activity Number: 289
• Type: Contributed
• Date/Time: Tuesday, August 5, 2014 : 8:30 AM to 10:20 AM
• Sponsor: ENAR
• Author(s): Zhongxue Chen*+
• Companies: Indiana University, Bloomington
• Keywords: combining p-values ; generalized genetic model ; trend test

Abstract

Due to the lack of powerful statistical tests, currently most of the GWAS data from the X chromosome were not analyzed and only a few significant associated SNPs from the X chromosome have been identified. We propose a novel statistical approach based on the generalized genetic model which utilizes the information of SNPs on the X chromosome from both males and females in an efficient way. The proposed approach avoids the need of making strong assumptions about the underlying genetic models. Our proposed statistical test is a robust method which does not assume any specific genetic model from which the data are generated. Through simulation studies and a real data application, we show that the proposed procedure is robust outperforms existing methods.