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Activity Number: 86
Type: Contributed
Date/Time: Sunday, August 3, 2014 : 4:00 PM to 5:50 PM
Sponsor: Section on Statistics and the Environment
Abstract #312714 View Presentation
Title: A Nonlinear Latent Variable Model for Repeated Follow-Up Data on Methylmercury Neurotoxicity
Author(s): Esben Budtz-Jørgensen*+
Companies: University of Copenhagen
Keywords: latent variable ; structural equation ; non-linear
Abstract:

Standard statistical procedures (such as mixed models) are poorly suited for analysis multivariate longitudinal data may lead to biased and inefficient estimation of the exposure-associated effects. We explore different structural equation models where, multivariate endpoints are considered to be manifestations of causally related latent variables. This structure may provide a parsimonious and more powerful representation of the exposure effect while properly accounting for measurement errors and the complex correlation structure typically encountered in such data. The standard model assumes that latent variables are linearly related. We consider different models relaxing this assumption and illustrate the methods using data from a prospective cohort study linking prenatal mercury exposure to multivariate cognitive test-scores collected at age 7, 14 and 22.


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