JSM 2014 Home
Online Program Home
My Program

Abstract Details

Activity Number: 123
Type: Contributed
Date/Time: Monday, August 4, 2014 : 8:30 AM to 10:20 AM
Sponsor: Section on Statistics in Imaging
Abstract #312245
Title: Statistical Models for Imaging and Genetic Data in Cocaine Addiction
Author(s): Shabnam Azadeh*+ and Brian P. Hobbs and Frederick G. Moeller and Veera Baladandayuthapani
Companies: MD Anderson Cancer Center and MD Anderson Cancer Center and Virginia Commonwealth University and MD Anderson Cancer Center
Keywords: Fractional Anisotropy ; Diffusion Tensor Imaging ; Bayesian Model Averaging ; Bayesian False Discovery Rates ; Prefiltered Rotationally Invariant Nonlocal Means
Abstract:

Chronic cocaine users have been shown to have subtle abnormalities in different area of the white matter by diffusion imaging techniques such as the anterior and posterior corpus callosum and in tracts in frontal and parietal regions of the brain. Also, reduced white matter fractional anisotropy (FA) is believed to be associated with disrupted integrity of white matter and fiber tracts by utilizing diffusion tensor imaging. However, the precise mechanisms yielding alterations in white matted remain unknown. In this study we examined the effect of twenty-one candidate SNPs, adjusted by sex, group, and age on FA changes through Bayesian voxel-based analysis. Three steps have been considered : i) Bayesian model averaging, ii) spatial smoothing posterior probability maps using prefiltered rotationally invariant nonlocal means , and iii) multiplicity correction using Bayesian false discovery rates.


Authors who are presenting talks have a * after their name.

Back to the full JSM 2014 program




2014 JSM Online Program Home

For information, contact jsm@amstat.org or phone (888) 231-3473.

If you have questions about the Professional Development program, please contact the Education Department.

The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.

ASA Meetings Department  •  732 North Washington Street, Alexandria, VA 22314  •  (703) 684-1221  •  meetings@amstat.org
Copyright © American Statistical Association.