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Activity Number: 297
Type: Contributed
Date/Time: Tuesday, August 5, 2014 : 8:30 AM to 10:20 AM
Sponsor: Section on Medical Devices and Diagnostics
Abstract #312009 View Presentation
Title: A Score Test for Detecting Heterogeneous Within-Group Variances in Linear Mixed Models
Author(s): Chul Ahn*+ and Nelson Lu
Companies: FDA-CDRH and FDA/CDRH
Keywords: Diagnostic test ; model violation ; heteroscadasticity ; score statistic
Abstract:

One of the common assumptions in linear mixed models is that the within-group variances are homogeneous. This paper investigates the impact of heterogeneous within-group variances on the estimate of a regression coefficient especially when the within-group variance depends on a group-level covariate. We also develop a diagnostic test based on score statistic to detect heterogeneous within-group variances in linear mixed linear models. The method is applied to the data from an orthopedic device clinical trial.


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