Mendelian Inheritance Transmission Disequilibrium Test with One Offspring

• Activity Number: 453
• Type: Contributed
• Date/Time: Wednesday, August 6, 2014 : 8:30 AM to 10:20 AM
• Sponsor: WNAR
• Author(s): Gulhan Bourget*+
• Companies: California State University, Fullerton
• Keywords: TDT ; Missing Genotypes ; Family-Based Association Test ; Mendelian Inheritance ; rTDT

Abstract

The Transmission Disequilibrium Test (TDT) is a family-based association test for linkage disequilibrium. The TDT measures the over-transmission of an allele from heterozygous parents to affected offspring. The TDT requires complete genotypes from parents and offspring. However, all genotypes might not be available. Many methods have been proposed to handle missing genotypes in parents, but a few in offspring. The robust TDT (rTDT) is one of the few methods that handle missing genotypes in parents with two affected offspring. In this talk, I propose Mendelian Inheritance Transmission Disequilibrium Test (MI-TDT) that takes population frequencies of the disease allele and marker allele into account in rTDT for families with one affected offspring. The Monte Carlo simulations show that MI-TDT has more power and controls type I error better than rTDT.