Abstract Details
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Activity Number:
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186
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Type:
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Contributed
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Date/Time:
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Monday, August 4, 2014 : 10:30 AM to 12:20 PM
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Sponsor:
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Biometrics Section
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Abstract #311880
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Title:
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Comparison of Storer's and mTPI Designs with Simulation
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Author(s):
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Hong Wang*+
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Companies:
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University of Pittsburgh Cancer Institute
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Keywords:
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Storer's design ;
mTPI design ;
clinical trial ;
maximum tolerated dose ;
simulation
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Abstract:
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In order to choose a design for a phase I clinical trial, a simulation study was performed to compare the operating characteristics of two rule-based dose-finding designs: the Storer's and the modified toxicity probability interval (mTPI) design, based on the dose setting and target regimen limiting toxicity (RLT) probability of the trial. Seven scenarios were simulated for the true underlying RLT rates under the doses. Based on the simulation, it was found that the mTPI design had higher probability of selecting the right dose as maximum tolerated dose (MTD) if at least one of the doses was safe, so we chose the mTPI design for this phase I trial. In this presentation, the simulation results are presented and discussed.
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Authors who are presenting talks have a * after their name.
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