Analysis of Binding Site Structure for Protein Function Prediction

• Activity Number: 378
• Type: Topic Contributed
• Date/Time: Tuesday, August 5, 2014 : 2:00 PM to 3:50 PM
• Sponsor: Section on Statistics in Imaging
• Author(s): Leif Ellingson*+
• Companies: Texas Tech University
• Keywords: algorithm ; classification ; bioinformatics ; protein function prediction

Abstract

It is known that the biological function of a protein is related in some way to its physical structure. This talk will focus on the structure of a protein's binding site, which is a location on the protein where binding activity is known to occur, and discuss how methods from geometry and statistics can be used to explore the relationship between structure and function. In particular, this talk will present a method for aligning pairs of binding sites to find atoms common to both, statistical methods for predicting protein function, and how geometry serves as both a tool and hindrance in the solving of these problems.