Abstract Details
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Activity Number:
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21
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Type:
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Topic Contributed
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Date/Time:
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Sunday, August 3, 2014 : 2:00 PM to 3:50 PM
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Sponsor:
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Biopharmaceutical Section
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Abstract #311659
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View Presentation
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Title:
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Drug Monitoring in Infectious Disease Therapy: Optimizing the Dose Individually and Dynamically
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Author(s):
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Alfred H. Balch*+
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Companies:
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University of Utah
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Keywords:
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Therapeutic Drug Monitoring ;
Adaptive Design ;
Dynamic Treatment Allocation ;
D-Optimality ;
Q-Learning
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Abstract:
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Pharmacokinetic (PK) monitoring is commonly employed for narrow therapeutic window drugs. These are drugs where the range of safe concentrations and the range of effective concentrations have a narrow intersection. Determining a safe and effective dose depends on feedback in the form of bacteria/virus/fungus culture, patient drug concentration, and patient laboratory values.
This research will review and compare drug administration policies based on stochastic control theory using Q-learning (Watkins (1989), Murphy (2005) and D-optimality (Aarons and Ogungbenro (2009)) and propose an optimal TDM-based algorithm for patients receiving narrow therapeutic window drugs.
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Authors who are presenting talks have a * after their name.
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