Simultaneous Inference for Low-Dose Risk Estimation with Abbott-Adjusted Quantal Response Models in Benchmark Analysis

• Activity Number: 125
• Type: Contributed
• Date/Time: Monday, August 4, 2014 : 8:30 AM to 10:20 AM
• Sponsor: SSC
• Author(s): Jianan Peng*+
• Companies: Acadia University
• Keywords: Simultaneous inference ; Benchmark dose ; Abbott-adjusted model

Abstract

Risk assessment studies where human, animal or ecological data are used to set safe low dose levels of a toxic agent is challenging as study information is limited to high dose levels of the agent. Buckley and Piegorsch (Statistical Methodology, 2008) developed the hyperbolic band for low dose inference for Abbott-adjusted quantal response models in quantitative risk analysis. However, the shape of the constant width band may be more desirable than that of the hyperbolic band in some applications in risk analysis as a confidence band should be narrower especially near the lower end of low doses. In this talk, we will show that a constant width band should do better than the hyperbolic band considered by Buckley and Piegorsch (2008).