Application of Network Meta-Analysis to Stroke Studies

• Activity Number: 233
• Type: Contributed
• Date/Time: Monday, August 4, 2014 : 2:00 PM to 3:50 PM
• Sponsor: Biopharmaceutical Section
• Author(s): Junyuan Wang*+ and Guang Yang and Weihua Tang and Min-ge Xie
• Companies: BMS and Rutgers University and BMS and Rutgers University
• Keywords: meta-analysis ; confidence distribution

Abstract

Meta-analysis provides a useful framework for combining information from disparate studies. It has been widely used in clinical trials to inference on drug efficacy. Xie, M., Singh, K., and Strawderman, W. (2011) proposed a unifying framework for meta-analysis based on confidence distribution approach. Yang, G., Liu, D., Liu, R., Xie, M., and Hoaglin, D. (2013) developed a network meta-analysis based on that framework. In this talk, we apply the network meta-analysis method to the data from stroke studies provided by Hart (2007) and demonstrate that the new method has several advantages over the traditional meta-analysis method used by Hart (2007).