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Activity Number: 625
Type: Invited
Date/Time: Thursday, August 7, 2014 : 10:30 AM to 12:20 PM
Sponsor: Biopharmaceutical Section
Abstract #310914 View Presentation
Title: Model-Based and Robust Methods for Analysis of Recurrent Hospitalization in Cardiovascular Trials
Author(s): Richard J. Cook*+
Companies: University of Waterloo
Keywords: recurrent events ; mortality ; rate function ; marginal methods ; robust inference
Abstract:

The assessment of treatment effects in clinical trials is routinely made based on simple comparisons of marginal features of a disease process. When trials involve multi-type or recurrent event outcomes (e.g. recurrent hospitalization) it can be challenging to define marginal features that adequately reflect the important distinct features of the disease process. This talk will consider some simple summary measures that can be robustly estimated along with alternative model-based methods that can be used to better understand and reflect the disease process. The approaches will be contrasted in terms of robustness, power for detecting treatment differences, and the insight they furnish on the response to treatment.


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