JSM 2014 Home
Online Program Home
My Program

Abstract Details

Activity Number: 210
Type: Invited
Date/Time: Monday, August 4, 2014 : 2:00 PM to 3:50 PM
Sponsor: Section on Statistics in Epidemiology
Abstract #310649 View Presentation
Title: A Unified Framework for Two-Stage Gene-Environment Interaction Tests with Adaptive Filtering
Author(s): Lin Chen*+
Companies: University of Chicago
Keywords: two-stage ; gene-environment interaction ; adaptive filtering
Abstract:

Complex diseases arise as the consequences of genetic, environmental risk factors and their interactions. Despite the established role of gene-environment interactions (GxE) in disease etiology, there are only a limited number of GxE effects being identified via genome-wide searches, due to power issues. To detect GxE effects with genome-wide association or whole-genome sequencing data, we propose a gene-based test with two unified steps -- filtering and testing. We propose to first conduct a filtering test on each genetic variant in the genome, apply an adaptive filtering to each gene and perform a gene-based interaction test only with the retaining variants. By employing an asymptotically independent filtering to the interaction test, we can obtain the exact distribution of the overall test statistics, and approximate its power function. We calculate the optimal filtering threshold for each gene adaptively to maximize the power, with considerations of potential linkage disequilibrium. The proposed two-stage testing frame also has a natural Bayesian interpretation. We demonstrate with simulations and examples that our test outperforms existing methods in the literature.


Authors who are presenting talks have a * after their name.

Back to the full JSM 2014 program




2014 JSM Online Program Home

For information, contact jsm@amstat.org or phone (888) 231-3473.

If you have questions about the Professional Development program, please contact the Education Department.

The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.

ASA Meetings Department  •  732 North Washington Street, Alexandria, VA 22314  •  (703) 684-1221  •  meetings@amstat.org
Copyright © American Statistical Association.