Abstract Details
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Activity Number:
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53
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Type:
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Invited
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Date/Time:
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Sunday, August 3, 2014 : 4:00 PM to 5:50 PM
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Sponsor:
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Section on Statistics in Epidemiology
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Abstract #310526
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Title:
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Random-Effects Meta-Analysis for a Systematic Review of Phase I Clinical Trials
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Author(s):
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Mi-Ok Kim and Xia Wang*+ and Chunyan Liu and Seongho Song
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Companies:
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Cincinnati Children's Hospital Medical Center and University of Cincinnati and Cincinnati Children's Hospital Medical Center and University of Cincinnati
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Keywords:
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meta-analysis ;
systematic review ;
sparse outcomes ;
missing data ;
semi-parametric Bayesian analysis
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Abstract:
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We review random-effects meta-analysis methods with an emphasis on the handling of sparse and incomplete data, and conduct a sensitivity analysis using a semi-parametric Bayesian analysis with mixtures of Dirichlet processes prior. A systematic review of pediatric phase I oncology trials provides a real life example where the absence of within-study comparison groups and a high percentage of zero or missing observations complicate a meta-analysis.
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Authors who are presenting talks have a * after their name.
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