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Activity Number: 568
Type: Invited
Date/Time: Wednesday, August 7, 2013 : 2:00 PM to 3:50 PM
Sponsor: IMS
Abstract - #310438
Title: Analysis of Shape Data Sets in the Brain and in the Heart
Author(s): Laurent Younes*+
Companies: Johns Hopkins University
Keywords:
Abstract:

We describe a processing pipeline for the analysis of large datasets of triangulated surfaces, arising from brain or cardiac medical images. Starting from segmented regions of interest (such as brain subvolumes, or cardiac ventricles), the pipeline executes the following sequence of operations: computation of a population average, or template, registration of all shapes on the template using large deformation diffeomorphic metric mapping algorithm (LDDMM) and statistical analyses of group differences based on deformation markers. The approach is illustrated by specific examples, involving Alzheimer's disease (BIOCARD, ADNI), Huntington disease (PREDICT) and hypertrophic cardiomyopathy.


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