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Activity Number: 137
Type: Contributed
Date/Time: Monday, August 5, 2013 : 8:30 AM to 10:20 AM
Sponsor: Section on Statistics in Epidemiology
Abstract - #310233
Title: Application of a Reconstructed Population Method to the Global Enteric Multicenter Study Mortality Data
Author(s): Yukun Wu*+ and Diluba Nasrin and Tamer Farag and Karen Kotloff and Myron Levine and Halvor Sommerfelt and William C. Blackwelder
Companies: University of Maryland School of Medicine and University of Maryland School of Medicine and University of Maryland School of Medicine and University of Maryland School of Medicine and University of Maryland School of Medicine and University of Bergen and University of Maryland School of Medicine
Keywords: case-control study with follow-up ; reconstructed population
Abstract:

Sommerfelt et al. (Clinical Infectious Diseases, 2012) introduced a reconstructed population method (RPM), which can estimate the association between risk factors and outcomes other than the one that defines case-control status. We apply this method to data from the Global Enteric Multicenter Study (GEMS), the centerpiece of which was a case-control study designed to describe acute moderate-to-severe diarrhea (MSD) in children 0-59 months of age. A feature of GEMS was follow-up at approximately 60 days after enrolling study participants, when the occurrence of outcomes other than MSD was determined. Using a Cox regression model, we use the RPM to estimate the hazard ratio of death given the presence of several pathogens, and we consider methods for estimating the variability of model coefficients.


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