Identifying Immune Response Combinations Associated with Heterogeneous Infectious Risk in HIV Vaccine Studies

• Activity Number: 175
• Type: Contributed
• Date/Time: Monday, August 5, 2013 : 10:30 AM to 12:20 PM
• Sponsor: Biometrics Section
• Author(s): Chaeryon Kang*+ and Ying Huang and Michael R. Kosorok
• Companies: Fred Hutchinson Cancer Research Center and Fred Hutchinson Cancer Research Center and The University of North Carolina-Chapel Hill
• Keywords: HIV vaccine/prevention ; Immune responses ; Correlates analysis ; Heterogeneous infection risk

Abstract

In HIV vaccine/prevention research, finding vaccine-induced immune responses that predicts the risk of HIV infection provides valuable information for the development of vaccine regimens. Previous correlates analysis of the Thai vaccine trial discovered interesting immune correlates related to HIV infection risk. In this study, we are interested in identifying the combinations of immune responses associated with heterogeneous infection risk. We look for a "change-line" by combining subset of immune responses which separates vaccine recipients into two heterogenous subgroups in terms of the risk of infection. The resulting marker combinations will then serve as candidate correlates of protection for predicting vaccine's protective effect on HIV infection. Application of the proposed statistical approach to the Thai trial is presented, where we search for marker combinations among twenty Variable Regions 1 and 2 (V1V2) of HIV-1 gp70 scaffolded proteins.