Abstract Details
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Activity Number:
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407
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Type:
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Topic Contributed
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Date/Time:
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Tuesday, August 6, 2013 : 2:00 PM to 3:50 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #309851 |
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Title:
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Improving Median Progression-Free Survival Methods Through Design or Analysis
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Author(s):
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Keaven Anderson*+ and Honghong Zhou
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Companies:
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Merck Research Laboratories and Merck Research Laboratories
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Keywords:
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progression free survival ;
clinical trials ;
survival
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Abstract:
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Median duration of progression free survival is often forms a crucial component in the comparison of two cancer regimens when trying to evaluate the benefit provided by a new treatment. Unfortunately, progression, the main component of this endpoint, is only assessed on a periodic basis which can lead to an unstable estimate of the difference in treatment group medians. We explore the value of adding progression evaluations or randomizing patients to non-overlapping schedules. We also explore the ability of parametric and nonparametric interval-censoring methods to improve estimation. A randomized scan schedule appears helpful in improving median comparisons.
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Authors who are presenting talks have a * after their name.
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