Abstract Details
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Activity Number:
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634
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Type:
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Topic Contributed
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Date/Time:
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Thursday, August 8, 2013 : 8:30 AM to 10:20 AM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #309725 |
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Title:
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Some Adaptive Enrichment Designs
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Author(s):
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Yonghong Gao*+
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Companies:
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US Dept of Health and Human Services
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Keywords:
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adaptive ;
subgroup ;
enrichment ;
clincial trial ;
simulation
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Abstract:
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Subgroup analyses are routinely conducted in analyzing data from clinical trials since variability in response across subgroups is frequently observed. In this paper we look at three two-stage adaptive designs where subgroup analyses are pre-planned as a formal component of the efficacy assessment. We apply those designs to a CRT trial data. We also compare the performance of the trial designs through simulation studies.
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Authors who are presenting talks have a * after their name.
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