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Activity Number: 581
Type: Topic Contributed
Date/Time: Wednesday, August 7, 2013 : 2:00 PM to 3:50 PM
Sponsor: Section on Statistical Consulting
Abstract - #309634
Title: Multiple Imputation for Competing Risk and Longitudinal Data with Informative Dropout
Author(s): Bo Hu*+
Companies: Cleveland Clinic
Keywords: Multiple imputation ; Informative dropout ; longitudinal data ; survival data
Abstract:

We propose a sequential multiple imputation (SMI) procedure to impute missing longitudinal and competing-risk survival data in the joint-modeling setting, where these two types of data are correlated and the survival outcome informatively censors the observations of the longitudinal outcomes. Our procedure uses a series of parametric regression models to impute the missing data in a sequential fashion. The procedure can handle complex competing-risk survival data and multivariate longitudinal data. We illustrate the SMI procedure by applying it to data from a longitudinal chronic kidney disease (CKD) study with 11-year follow-up. The proposed SMI procedure can be widely applied in longitudinal studies.


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