Overview of Pharmacogenomics, Gene-Gene Interaction, System Genomics

• Activity Number: 229
• Type: Topic Contributed
• Date/Time: Monday, August 5, 2013 : 2:00 PM to 3:50 PM
• Sponsor: Biopharmaceutical Section
• Author(s): Marylyn Ritchie*+
• Companies: The Pennsylvania State University
• Keywords: systems genomics ; pharmacogenomics ; personalized medicine ; polygenic modeling

Abstract

Personalized medicine, or more recently coined precision medicine, has advanced as one of the predominant strategic initiatives and goals of the next decade for many pharmaceutical companies, biotech institutes, academic medical centers, and the National Institutes of Health. The primary goal of this type of initiative is to treat patients with the correct dose of the appropriate medication based on their individual demographic and genomic. Pharmacogenetics and pharmacogenomics have made the dreams of precision medicine a reality. While great strides have been made in pharmacogenomics, a number of analytic challenges have emerged related to study design and data analysis. To overcome these challenges, new strategies are being developed to explore integrative systems genomics analyses, polygenic modeling, and genome-wide approaches. These alternative methods will be discussed along with data driven examples. The discovery of genomic models that associate with drug response is paramount to success in personalized medicine.