Abstract Details
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Activity Number:
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76
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Type:
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Contributed
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Date/Time:
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Sunday, August 4, 2013 : 4:00 PM to 5:50 PM
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Sponsor:
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Biometrics Section
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| Abstract - #309418 |
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Title:
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Estimate of Search Method Coherence by Using Repeated Probes on Tiled Microarrays
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Author(s):
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Sigrún Helga Lund*+ and Gunnar Stefansson and Thorunn Rafnar and Daniel Gudbjartsson
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Companies:
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University of Iceland and University of Iceland and Decode and Decode
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Keywords:
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TileShuffle ;
tiled microarrays ;
prostate cancer ;
repeated probes ;
lncRNA
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Abstract:
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Long non-coding RNAs (lncRNAs) have been proposed as biomarkers in prostate cancer. Data from tiled microarrays is used to identify relatively long regions that are expressed in prostate cancer tissue. In this paper the TileShuffle method is evaluated as a search method for candidate lncRNAs in locus 8q24.2. The method is run on three microarrays, all containing the same samples as well as repeated copies of tiled probes. This allows the coherence of the selection method within and between microarrays to be estimated by Monte Carlo simulations on the repeated probes. The results show considerable variability in which areas are selected both between microarrays and between selected probesets within a microarray.
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Authors who are presenting talks have a * after their name.
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