Abstract Details
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Activity Number:
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497
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Type:
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Contributed
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Date/Time:
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Wednesday, August 7, 2013 : 8:30 AM to 10:20 AM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #309285 |
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Title:
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Testing Individual Hypotheses Marginally at Alpha: Comparisons of Available Methods
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Author(s):
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David Li*+
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Companies:
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Pfizer
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Keywords:
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Multiple testing ;
Consistency ;
probability of success
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Abstract:
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When a trial has one primary endpoint but two testing doses, a multiple comparison procedure is to be specified to control the family-wise error rate at alpha across 2 doses. To maximize the probability of success, the procedures which permit to test each dose marginally at alpha is desired. One common procedure is to pool the doses and test the pooled data first. If the endpoint is positive for pooled data, then test the individual doses at alpha. Another procedure is to pre-specify a consistency criterion and test the individual doses at alpha if the consistency criterion is met. This presentation will compare these two methods and provide guidance on when each method should be used.
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Authors who are presenting talks have a * after their name.
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