Abstract Details
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Activity Number:
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547
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Type:
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Contributed
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Date/Time:
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Wednesday, August 7, 2013 : 10:30 AM to 12:20 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #308927 |
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Title:
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Statistical Quantification of Drug-Related Arrhythmia
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Author(s):
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Kai-Fen Wang*+ and Paul McAllister and Eric Rossman
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Companies:
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GlaxoSmithKline and GlaxoSmithKline and GlaxoSmithKline
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Keywords:
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Arrhythmias ;
Cardiovascular safety ;
Background ;
Drug-induced ;
Pattern based approach
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Abstract:
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Current methodologies, used to determine if arrhythmias are drug-induced in cardiovascular safety studies, often focus solely upon the comparison between pre- and post-dose quantities. However, due to the background incidence of arrhythmias in larger species (i.e. dog or monkey), these comparisons have proved to be quite difficult and frequently lead to inconclusive results. In lieu of this, we have recently created a statistical model using a pattern based approach, which can be used to differentiate between background and drug-induced ventricular arrhythmias in dogs.
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Authors who are presenting talks have a * after their name.
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