Abstract Details
Activity Number:
|
226
|
Type:
|
Topic Contributed
|
Date/Time:
|
Monday, August 5, 2013 : 2:00 PM to 3:50 PM
|
Sponsor:
|
Biometrics Section
|
Abstract - #308739 |
Title:
|
Calibration in the Continual Reassessment Method for Phase I Clinical Trials
|
Author(s):
|
Xiaoyu Jia*+ and Shing M. Lee
|
Companies:
|
Columbia University and Columbia University
|
Keywords:
|
dose finding ;
calibration ;
two-stage continual reassessment method
|
Abstract:
|
The continual reassessment method is an adaptive model-based design used to estimate the maximum tolerated dose in phase I clinical trials. In finite sample settings, it is important to specify a reasonable model. We propose a systematic approach to calibrate the two-stage continual reassessment method whereby model based dose escalation is activated after an initial sequence of patients are tested on lower dose levels. The calibration approach is based on the concepts of indifference interval and coherence. We compare the approaches to the traditional trial and error approach in the context of examples. The models selected by the systematic approach are competitive to the models obtained through a time consuming trial and error process. The semi-automatic calibration approaches simplify the model calibration process for the continual reassessment method. We also share our experience using the calibration technique in real life applications using the dfcrm package in R.
|
Authors who are presenting talks have a * after their name.
Back to the full JSM 2013 program
|
2013 JSM Online Program Home
For information, contact jsm@amstat.org or phone (888) 231-3473.
If you have questions about the Continuing Education program, please contact the Education Department.
The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.
Copyright © American Statistical Association.