Abstract Details
Activity Number:
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17
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Type:
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Topic Contributed
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Date/Time:
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Sunday, August 4, 2013 : 2:00 PM to 3:50 PM
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Sponsor:
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Biopharmaceutical Section
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Abstract - #308573 |
Title:
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Smart Design for Comparing Adaptive Interventions
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Author(s):
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Min Qian*+ and Inbal Nahum-Shani and Daniel Almirall and Susan Murphy
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Companies:
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Columbia University and University of Michigan and University of Michigan and University of Michigan
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Keywords:
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Dynamic treatment regimes ;
sequential randomization ;
treatment policy
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Abstract:
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Research in the area of intervention development is shifting from the traditional fixed-intervention approach to adaptive interventions, which allow greater individualization and adaptation of intervention options (i.e., intervention type and/or dosage) over time. Adaptive interventions are operationalized via a sequence of decision rules that specify how intervention options should be adapted to an individual's characteristics and changing needs, with the general aim to optimize the long-term effectiveness of the intervention. We propose the use of sequential multiple assignment randomized trial (SMART) design for addressing research questions that inform the construction of high-quality adaptive interventions We also provide Methods for analyzing data from SMART to address primary research questions that inform the construction of a high-quality adaptive intervention. Comparison of SMART with other experimental approaches will be made as well.
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Authors who are presenting talks have a * after their name.
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