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Activity Number: 72
Type: Topic Contributed
Date/Time: Sunday, August 4, 2013 : 4:00 PM to 5:50 PM
Sponsor: Section on Statistics and the Environment
Abstract - #308366
Title: Estimating Potency in Multiple Endpoints in Aquatic Toxicity Testing
Author(s): Jing Zhang*+ and A. John Bailer and James T. Oris
Companies: Miami University and Miami University and Miami University
Keywords: Toxicology ; Bayesian hierarchical modeling ; Multivariate ; effective concentration
Abstract:

Chemicals from effluents may impact the mortality, growth, or reproduction of organisms in the aquatic systems. These endpoints are typically analyzed separately while these are essentially hierarchical responses and hence highly correlated. In the present study, we propose using a Bayesian hierarchical model to analyze these responses in aquatic toxicology experiments jointly and to estimate the response-specific concentration associated with a specified level of survival/growth/reproductive inhibition. A simulation studies showed that the proposed models outperformed existing approaches where these related hierarchical responses were modeled separately. This method suggests an alternative way of assessing the toxicity of chemicals. The application of the proposed models is illustrated with an experiment where the impact of a particular chemical was studied.


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