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Activity Number: 416
Type: Topic Contributed
Date/Time: Tuesday, August 6, 2013 : 2:00 PM to 3:50 PM
Sponsor: Section on Statistics in Epidemiology
Abstract - #308325
Title: Structural Nested Mean Model for Clustered Outcomes
Author(s): Jiwei He*+ and Marshall M. Joffe
Companies: University of Pennsylvania and University of Pennsylvania
Keywords: causal inference ; clustered outcomes ; optimal estimating equation
Abstract:

Structural nested models (SNMs) are useful in dealing with confounding by variables affected by treatment. Two types of SNMs are structural nested mean models (SNMMs) and structural nested distribution models (SNDMs). We extend SNMMs to clustered observations. We consider how to formulate models with both cluster- and individual-level treatments, and show how to derive semiparametric estimators of parameters in those models. The properties of parameter estimators are evaluated through simulations. We use a dataset in ophthalmology to illustrate our method.


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