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Activity Number: 69
Type: Topic Contributed
Date/Time: Sunday, August 4, 2013 : 4:00 PM to 5:50 PM
Sponsor: Biopharmaceutical Section
Abstract - #308140
Title: The Role of Pragmatic Trials in Comparative Effectiveness Research
Author(s): Lehana Thabane*+ and Janusz Kaczorowski and Lisa Dolovich and Larry Chambers and On behalf of the CHAP Investigators
Companies: St Joseph's Healthcare Hamilton and Universite de Montreal and McMaster University and University of Ottawa and McMaster University
Keywords: pragmatic trials; comparative effectiveness research; real world setting
Abstract:

Pragmatic trials play a major role in assessing the effectiveness of interventions in the real world. They address a fundmental question of whether offering an intervention, therapy or drug versus some control--which could be usual care or standard of care--does more good than harm in some defined population or setting. Unfortunately, there are many criticims and controversies about pragmatic trials. This presentation will address these confusions and use the CHAP trial (BMJ 2011;342:d442) to illustrate how to deal with the issues.


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