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Activity Number: 653
Type: Contributed
Date/Time: Thursday, August 8, 2013 : 8:30 AM to 10:20 AM
Sponsor: Section on Bayesian Statistical Science
Abstract - #308053
Title: Expediting Clinical and Translational Research via Bayesian Instrument Development
Author(s): Yu Jiang*+ and Diane K. Boyle and Marjorie J. Bott and Jo A. Wick and Qing Yu and Byron Gajewski
Companies: University of Kansas Medical Center and University of Kansas School of Nursing and University of Kansas School of Nursing and University of Kansas Medical Center and University of Kansas Medical Center and Univ of Kansas-Medical Center
Keywords: BID ; reliability ; content validity ; construct validity ; patient reported outcomes
Abstract:

Developing valid and reliable instruments is crucial but costly and time-consuming in health care research and evaluation. The Food and Drug Administration and the National Institutes of Health have set up guidelines for developing patient-reported outcome instruments. However, the guidelines are not applicable to cases of small sample sizes. Instead of using an exact estimation procedure to examine psychometric properties, our Bayesian Instrument Development (BID) method integrates expert data and participant data into a single seamless analysis. Using a novel set of priors, we use simulated data to compare BID to classical instrument development procedures and test the stability of BID. To display BID to nonstatisticians, a graphical user interface based on R and WINBUGS is developed and demonstrated with data on a small sample of heart failure patients. Costs were saved by eliminating the need for unnecessary continuation of data collection for larger samples as required by the classical instrument development approach.


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