Abstract Details
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Activity Number:
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8
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Type:
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Invited
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Date/Time:
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Sunday, August 4, 2013 : 2:00 PM to 3:50 PM
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Sponsor:
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Section on Statistics in Epidemiology
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| Abstract - #307527 |
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Title:
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Using Family Members to Augment Genetic Case-Control Studies of a Life-Threatening Disease
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Author(s):
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Jinbo Chen and Lu Chen*+ and Clarice R. Weinberg
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Companies:
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University of Pennsylvania School of Medicine and University of Pennsylvania and National Institute of Environmental Health
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Keywords:
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Abstract:
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Survival bias may arise in case-control genetic association studies if there is an association between survival and genetic variants under study. It is difficult to detect and adjust for the bias if no genetic data are available from deceased cases. We propose to incorporate genotype data from family members (such as offspring, spouses, or parents) of deceased cases and a semiparametric method for data analysis. Our method permits unbiased estimation of genotype association parameters. Our proposed method can improve both validity and study power by incorporating missing data from deceased cases, and we provide simulations to demonstrate achievable improvements in efficiency.
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Authors who are presenting talks have a * after their name.
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