Abstract Details
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Activity Number:
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462
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Type:
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Invited
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Date/Time:
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Wednesday, August 7, 2013 : 8:30 AM to 10:20 AM
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Sponsor:
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International Chinese Statistical Association
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| Abstract - #307519 |
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Title:
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The Use of Risk Models in Disease Prevention
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Author(s):
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Mitchell Gail*+
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Companies:
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National Cancer Institute
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Keywords:
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cumulative incidence ;
absolute risk ;
disease prevention ;
risk-benefit ;
breast cancer ;
resource allocation
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Abstract:
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I define the absolute risk of breast cancer, sometimes called "crude risk" or "cumulative incidence", and discuss its applications in advising individual patients at risk of breast cancer and in public health applications. Deciding whether or not to take tamoxifen to prevent breast cancer is an example of the former. Designing prevention trials, implementing "high risk" prevention strategies, and using risk estimates to allocate prevention resources under cost constraints are examples of the latter. The distribution of absolute risk in the general population plays a key role in assessing the utility of a risk model in these applications and in assessing how much additional risk factors, such as genotypes of single nucleotide polymorphisms (SNPs), improve performance.
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Authors who are presenting talks have a * after their name.
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