Abstract Details
Activity Number:
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659
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Type:
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Invited
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Date/Time:
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Thursday, August 8, 2013 : 10:30 AM to 12:20 PM
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Sponsor:
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Section on Statistics in Epidemiology
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Abstract - #307305 |
Title:
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Heritability Estimation Based on Survival Data
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Author(s):
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Malka Gorfine*+ and Li Hsu
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Companies:
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Technion - Israel Institute of Technology and Fred Hutchinson Cancer Research Center
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Keywords:
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heritability ;
survuval model ;
GWAS ;
genetic and environmental effects
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Abstract:
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An important aspect of studying the etiology of complex disease is to understand the genetic and environmental contributions. Heritability is a commonly used measure for describing the phenotypic variation due to genetics. Recently, genome-wide association studies (GWAS) have identified thousands of loci for many complex traits. However, these variants only capture a few percent of the estimated heritability of human complex traits and diseases, leaving open the question of where is the remaining heritability. Suggested explanations for this gap include gene-gene and gene-environmental interactions unidentified by the univariate GWAS analysis; unidentified contributions of rare genetic variants; or by overestimating the total heritability and creating "phantom heritability". In this talk we present a new method for estimation of heritability of complex disease traits based on a multivariate approach and time-to-event regression models.
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Authors who are presenting talks have a * after their name.
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