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Activity Number: 150
Type: Invited
Date/Time: Monday, August 5, 2013 : 10:30 AM to 12:20 PM
Sponsor: Health Policy Statistics Section
Abstract - #307049
Title: A Propensity Score Design That Parallels a Large Randomized Experiment: Effect of Single Versus Double Embryo Transfer for in Vitro Fertilization
Author(s): Cassandra Wolos Pattanayak*+ and Donald B. Rubin
Companies: Harvard University and Harvard University
Keywords: propensity scores ; observational studies ; Rubin Causal Model ; causal inference
Abstract:

Transferring one rather than two embryos during in vitro fertilization has been endorsed as a way to reduce multiple birth rates, but no large-scale randomized trial has evaluated the impact of the number of embryos transferred on birth outcomes. This presentation describes the design of an observational study that parallels a hypothetical randomized experiment to address the effect of single versus double embryo transfer. The data include 62,295 first-time fresh non-donor IVF cycles reported to the U.S. Assisted Reproductive Technology Surveillance Database between 2004 and 2008 in which at least three embryos were available and either one or two embryos were transferred three or five days after oocyte retrieval. Single and double embryo cycles were paired on estimated propensity scores to create matched treated and control groups that are as similar on the observed background covariates as if the number of embryos transferred had been randomly assigned. Key covariates were identified and prioritized in collaboration with physicians and experts at the Centers for Disease Control and Prevention, who also approved the balance created on observed covariates prior to outcome analysis.


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