JSM 2012 Online Program

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CE_38T	Wed, 8/1/2012, 1:00 PM - 2:45 PM	HQ-Indigo 206
25 Years of Cytel Exact Software: Overview of StatXact for Nonparametric Tests with Special Application to Correlated Categorical Data — Continuing Education CTW
ASA , Cytel Software Corporation
Instructor(s): Christopher D Corcoran, Utah State University, Pralay Senchaudhuri, Cytel Inc.
"In celebration of the 25th anniversary of the initial release of StatXact®, we'll review the fundamentals of performing exact inference for non-parametric tests as implemented in Cytel's industry standard software. Small and sparse samples of correlated categorical data arise frequently in applied research, often where observations are clustered - also in multi-center clinical trials, epidemiologic and genetic disease studies, and in developmental toxicology experiments. In these and other difficult settings, the large-sample assumptions underlying parametric models (e.g., using random effects) or marginal models (e.g., GEE) break down. We'll present exact alternatives, including a broad approach for permutation testing providing exact correlated-data analogues for conventional tests including Fisher's exact test, the trend test, the Wilcoxon, and Kruskal-Wallis test for doubly-ordered tables. Using practical examples, appropriate use of these tests in StatXact® - and a new SAS PROC - will be demonstrated. "

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