JSM 2012 Online Program

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CE_35T	Wed, 8/1/2012, 1:00 PM - 2:45 PM	HQ-Indigo A
Group Sequential Analysis Using SAS Software — Continuing Education CTW
ASA , SAS
Instructor(s): Yang Yuan, SAS Institute
A group sequential trial provides for interim analyses before completion of a clinical trial. Group sequential methods can help prevent unnecessary exposure of patients to an unsafe new drug, or alternatively, to a placebo treatment if a new drug shows tremendous promise. This workshop reviews basic concepts of group sequential analysis and introduces two SAS/STAT® procedures: SEQDESIGN and SEQTEST. The SEQDESIGN procedure creates group sequential designs by computing boundary values with a variety of methods, including the O'Brien-Fleming, Whitehead, and error spending methods; it also computes required sample sizes. The SEQTEST procedure compares the test statistic with the corresponding boundary values at each stage so that the trial can be stopped to reject or accept the hypothesis; it also computes parameter estimates, confidence limits, and p-values. Numerous examples illustrate the capabilities of the software. Attendees should be familiar with hypothesis testing and with other SAS/STAT procedures such as the REG and LOGISTIC procedures.

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