The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.
Online Program Home
Abstract Details
|
Activity Number:
|
542
|
|
Type:
|
Invited
|
|
Date/Time:
|
Wednesday, August 1, 2012 : 2:00 PM to 3:50 PM
|
|
Sponsor:
|
Biopharmaceutical Section
|
| Abstract - #306879 |
|
Title:
|
Lessons Learned from the Carcinogenicity Working Group: From Biomarker Discovery to Predictive Modeling
|
|
Author(s):
|
Alex Adai*+
|
|
Companies:
|
Asuragen, Inc.
|
|
Address:
|
2150 Woodward, Suite 100, Austin, TX, 78744,
|
|
Keywords:
|
|
|
Abstract:
|
As a potential first step in the safety assessment of nongenotoxic carcinogens, the C-Path Carcinogenicity Working Group (CWG) designed and implemented a quantitative PCR-based signature to predict nongenotoxic compounds that induce liver tumors in the rat (Fielden et al. 2011 Toxicol. Sci.). Although this signature is specific to the application of predicting toxicity, we developed a computational workflow that is relevant to model building in different biological contexts. This presentation will discuss the challenges typical in biomarker studies within the context of predicting nongenotoxic hepatocarcinogens: building an unbiased predictive model; evaluating model precision; and establishing model equivalency between platforms.
|
The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
Back to the full JSM 2012 program
|
2012 JSM Online Program Home
For information, contact jsm@amstat.org or phone (888) 231-3473.
If you have questions about the Continuing Education program, please contact the Education Department.